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iphone 8 case Sign in / Join NowSummaryCelldex has finished enrolling patients in the METRIC trial.The Company has few drugs in development that are quietly flying under the radar.The cash (plus anticipated proceeds from the future sales of its common stock under the agreement with Cantor) will be sufficient to fund planned operations through 2018.Last May I wrote a column about Celldex Therapeutics (CLDX), and the conclusion that I have come to was this:Varlilumab's data at ASCO might be disappointing, but I think that's what everybody expects. A less risky strategy could be starting a position after the meeting, riding the share price up, and sell before the release of the METRIC data[.]Well, varlilumab's data are no cause for enthusiasm, but the disappointment was not completely priced in.CLDX data by YChartsI have started a position in Celldex after ASCO and I want to share with you the reasons which led me to do so. Given the width of the company's pipeline, the column will be divided into two parts: in the first part I'll catch you up on where we are, while in the second one (which will be published in a few days) I'll give you an evaluation of the different programs.Well, first off, a brief update.Celldex and ASCO VarlilumabThe company presented updated data from the 1 trial of varlilumab in combination with Bristol Myers' (BMY) nivolumab in an oral presentation at the American Society of Clinical Oncology (ASCO) meeting.The presentation included data from 36 patients with advanced solid tumors (twentyone with colorectal cancer, eight with ovarian cancer, four with melanoma, and three with head and neck carcinoma).The patients were divided across three dosing cohorts: 0.1, 1.0 or 10 mg/kg on a Q2W schedule with a fixed dose of nivolumab (3 mg/kg Q2W) for the first four cycles followed by nivolumab mono therapy.Three partial responses were observed:One patient with PD L1 negative colorectal cancer (95% shrinkage) who continues to receive treatment at 22 months; One patient with low PD L1 (5%) head and neck cancer (59% shrinkage) and he experienced a progression free survival (PFS) of 6.7 months; One patient with PD L1 negative ovarian cancer experienced a single time point partial response (49% shrinkage; uPR) but she discontinued treatment due to a dose limiting toxicity (or DLT).iphone 8 case
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